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What is Sermorelin?

Sermorelin is a synthetic (man-made) version of a naturally occurring substance that causes release of growth hormone from the pituitary gland.

Growth hormone is naturally produced by the pituitary gland and is necessary for growth in children. In children who fail to grow normally because their bodies are not producing enough growth hormone, this medicine may be used to increase the amount of growth hormone produced by the pituitary gland.

A molecule called the growth hormone-releasing hormone (GHRH) controls hGH by releasing it from the pituitary gland into the bloodstream. If your blood test indicates low levels of hGH, your doctor may recommend injections of a synthetic form of GHRH, called sermorelin.

Sermorelin basic information

Molecular Formula: C149H246N44O42S
Molecular Weight: 3357.96
Appearance: White powder
Single Impurity (HPLC): 1.0%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): ≥80.0%
Acetate Content (HPIC): ≤12.0%
Water Content (Karl Fischer): ≤8.0%
Specific Rotation (20/D): -80.0～-90.0°(c=0.5 1%HAc)
Mass Balance: 95.0~105.0%
MS (ESI): Consistent

How does Sermorelin works?

Sermorelin essentially mimics the hypothalamic peptide, GHRH. It acts directly on the pituitary stimulating the somatotroph cells ability to produce and secrete GH.

Sermorelin increases proliferation of somatotroph cells during development. With the increase of serum GH, downstream effects occur.

A notable hormone that is commonly used as a surrogate for growth hormone therapy, insulin like growth factor 1 (IGF-1), is known to increase with the administration of Sermorelin. IGF-I negatively regulates GHRH-mediated GH secretion.

Sermorelin is able to influence the concert of hormonal signaling that effects the GH axis. GH secretion from the anterior pituitary is regulated by GHRH, somatostatin, and GH secretagogues.

The positive and negative opposing regulation of growth hormone by GHRH and somatostatin creates a rhythmic-circadian GH secretion. GH asked by signaling target cells, most notably increasing the synthesis of IGF-1 in the liver and peripheral tissues.

Sermorelin acts on the growth GHRHr in the pituitary to regulate cellular actives. GHRHr is the natural receptor for the endogenous hormone GHRH, a signaling hormone produced by the hypothalamus. This receptor among many other functions, controls growth hormone release, mainly by inhibition of somatostatin activity.

Sermorelin benefits

• Fat reduction
• Increased strength
• Increased lean body mass
• Increased vitality
• Improved energy
• Accelerated wound healing
• Increased endurance
• Improved bone density
• Improved cardiovascular and immune function
• Better sleep quality
• Improved skin quality and higher collagen density

Sermorelin Therapy Benefits

1) Improved cognitive function (better mental clarity), better vision, better bone health, enhanced immune system, stronger heart, and improved cardiovascular function.

2) Increase in muscle mass development after exercise, faster recovery from strenuous exercise, increased energy and endurance, better strength, and joint and muscle pain relief for patients with arthritis and chronic pain.

3) Accelerated healing from wounds or surgery, increase in libido and better sexual performance, improved sleep quality, and better mood.

4) Fat reduction (especially abdominal fat), restored vitality, youthful and glowing skin, thicker hair and nails, and an improved sense of well-being.

Sermorelin Side effects

The most common side effect of sermorelin is caused by its injection under your skin, it includes itching, pain, sensitivity, redness, swelling, irritation

These reactions are typically short-lived and disappear without any action.

As you get better at self-administering the shots, these symptoms may stop for good.

Sermorelin Storage

Store in the refrigerator. Do not freeze. Keep out of the reach of children.

Reference:

[1] Chang Y, et al. (2021). A potentially effective drug for patients with recurrent glioma: sermorelin.

[2] Furman BL. (2017). Sermorelin. 

[3] Lal RA, et al. (2019). Perspectives on long-acting growth hormone therapy in children and adults.

[4] Thorner M, et al. (1996). Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group. 

[5] Ishida J, et al. (2020). Growth hormone secretagogues: history, mechanism of action, and clinical development.