99.6% Purity Gonadorelin peptide for sale from China Growth Hormone supplier factory price top quality

What is Gonadorelin?

Gonadotropin-releasing hormone peptide hormone (GnRH; or also known as luteinizing hormone-releasing hormone (LHRH)) is a gonadotropin-releasing hormone receptor (GnRHR; LHRHR) agonist.

The international non-proprietary name for gonadotropin-releasing hormone dosage form is Gonadorelin; and this drug is a form of endogenous GnRH and is identical to it in chemical structure.

GnRH is produced by neuroendocrine cells within the hypothalamus. It is considered to be a neuronal hormone because it is produced by certain nerve cells.

The key area for GnRH production is the hypothalamic preoptic area (POA), which contains the majority of GnRH-secreting neurons. Similar to GH (growth hormone) secretion, GnRH is also pulsatilely secreted.

GnRH induces the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) gonadotropins from the anterior pituitary, and their release is the first step in the working system of the hypothalamic-pituitary-gonadial axis, resulting in increased significant in blood testosterone levels in men.

Gonadorelin peptide test report

Purity (HPLC): 98.0%min.
Single Impurity (HPLC): 0.5%max
Amino Acid Composition: ±10% of theoretical
Acetate Content(HPIC): ≤10.0%
Specific Rotation (20/D): -55.0～-65.0°(c=1 1%HAc)
Peptide Content (N%): ≥80.0%
Water Content(Karl Fischer): ≤8.0%
Mass Balance: 95.0~105.0%
MS (ESI): Consistent

Gonadorelin dosage Trt

Gonadorelin should only be administered by a healthcare provider, and when used, the response to this medication should be monitored with LH, basal LH, or serum sex steroid levels during therapy as needed.

Usual adult dose for medical purposes in treating gonadotropin deficiency and hypogonadotropic hypogonadism conditions is 100 mcg injected once subcutaneously or intravenously as a single dose.

And the usual adult dose in the treatment of amenorrhea is 5 mcg every 90 minutes (range 1 to 20 mcg), administered intravenously by pump for 1 minute, every 90 minutes for 21 days.

Gonadorelin benefits for males | Gonadorelin Uses

• Boost your libido
• Regulate and normalize testosterone levels
• Prevent testicular shrinkage
• Gonadorelin can increase your fertility
• Gonadorelin helps increase sperm count and volume in men and increase testosterone production.
• Stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH)
• Increase testicular size
• Gonadorelin can also be administered via injection to check whether the pituitary gland produces LH and FSH at the correct levels.
• Prevent the increase in estradiol, an estrogen hormone

Gonadorelin with Testosterone

If you are also taking prescribed testosterone therapy, this may impact the efficacy of gonadorelin.

We want our male patients to experience their full potential health, including making sure their testosterone levels are in the target range.

However, keeping testosterone in this target range all the time may suppress the hypothalamus’ natural release of GnRH.

This is where gonadorelin comes in: it will bypass the hypothalamus to stimulate the anterior pituitary to release LH and FSH directly.

This ensures that your testosterone levels stay high without any negative drawbacks for the rest of your body.

Gonadorelin side effects

Gonadorelin overdose or misuse leads to a decrease in LH and FSH levels and hypogonadism, Hot flashes (a sudden wave of mild or intense body heat), sweating, Irritation at the injection site (pain, swelling, or itching), nausea, dizziness, Headache, Washed, Rashes

Reference

[1] Endo, N., Nagai, K., Tanaka, T., & Kamomae, H. (2013). Progesterone profiles in the caudal vena cava and jugular vein in response to pulsatile luteinizing hormone stimulation induced by GnRH treatment during the mid-luteal phase in lactating dairy cows. Journal of Reproduction and Development, 2012-191.

[2] Rastogi, S., Shukla, S., Kalaivani, M., & Singh, G. N. (2018). Peptide-based therapeutics: Quality specifications, regulatory considerations, and prospects. Drug discovery today.

[3] Akın, O., Yavuz, S. T., Hacıhamdioğlu, B., Sarı, E., Gürsel, O., & Yeşilkaya, E. (2015). Anaphylaxis to gonadorelin acetate in a girl with central precocious puberty. Journal of Pediatric Endocrinology and Metabolism, 28(11-12), 1387-1389.