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What is DSIP Peptide?

The DSIP or the Delta sleep-inducing Peptide is a somnogeneric nonapeptide that impacts the neuromodulation.

It is typically found in the brain and passes by the blood barriers quite quickly. Studies have shown that DSIP and as well as its analogs are classified as peptide neuromodulators.

It has been used for the treatment of poor sleep, pain conditions, stress-related symptoms, low testosterone (via stimulation of LH), and even sometimes as an antioxidant and anti-cancer protein.

It exhibits a pronounced stress protective action and decreases stress-induced metabolic and functional disorders in human and animal organisms exposed to a variety of stresses. It has also been shown in research to improve hormone levels and physical performance.

DSIP has been described by the medical world to be a sleep-promoting substance rather than a form of sedative. It can give a modular effect on sleep and waking up functions.

This peptide only has few effects on the healthy subjects who are not suffering from sleep disturbance.

DSIP can be prescribed in conjunction with a low dose of peptide Epitalon to promote healthy sleep regulation, especially for jet lag. It increases deep sleep delta waves in the brain, and can also be used to mitigate various pain conditions, drug and alcohol withdrawal, and stress syndromes.

DSIP Benefits

• Can promote LH and GH release
• Can restore disturbed sleep patterns
• Can modulate cortisol production
• Can reduce persistent/chronic pain

DSIP dosage for sleep

For the suggested dosage, you may inject 0.1mL subcutaneously once daily at bedtime.

Although, it is not recommended to give out DSIP just before going to bed. The dose should be given during the day to help improve sleep the next night and as well as several days to come.

But you must remember that DSIP only works for short-term benefits and not for long-term management for insomnia.

DSIP and Hormones:

In humans, DSIP influences the secretion of adrenocorticotropic hormone (ACTH), luteinizing hormone (LH) and growth hormone (GH). It also plays a role in the regulation of circadian rhythms.

It is involved in neuroendocrine regulation and release of anterior pituitary hormones. Administration of DSIP seems to improve the hormone production/regulation in these glands.

For example, it increases LH and growth hormone production while decreasing somatostatin. This results in increased production of desirable hormones (LH, GH), and decreased the production of undesirable ones (cortisol and somatostatin).

DSIP peptide side effects

As DSIP is naturally occurring, side-effects are uncommon.

Normally, DSIP concentrations in the body are quite low so an injection of a large non-physiological dose might be expected to lead to adverse effects. However, no significant side-effects have been reported with DSIP.

In some people, an occasional headache, nausea or vertigo have been reported but these are only temporary. DSIP actually appears to be incredibly safe. In experiments, it has also been safe on animals at any dose administered.

Reference

Huang J.-T., and Lajtha A., 1978. The degradation of a nonapeptide, sleep-inducing-peptide, in rat brain: comparison with enkephalin breakdown. Res. Commun. chem. Path. Pharm.19, 191. PubMed Google Scholar

Graf M., Monnier M., Schneider-Helmert D., and Schoenenberger G.A. 1980. DSIP: A circadian ‘pace-maker’? In: Progress in Neuro-Pharmacology, p. 251. Ed. Radouco-Thomas C., Garcia F. Pergamon Press, Oxford-New York-Toronto-Sydney-Paris-Frankfurt. Google Scholar

Graf M., Lorez H.P., Gillesen D., Tobler H.J., and Schoenenberger G.A., 1981. Distribution and specific binding of³H-DSIP. Experientia37, 23. Google Scholar

Hoddes E., Zarcone V., Smythe H., Phillips R., and Dement W. C., 1973. Quantification of sleepiness: a new approach. Psychophysiology10, 431. PubMed Google Scholar