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What is kisspeptin 10?

Kisspeptins are natural ligands encoded by the KiSS-1 gene for G protein-coupled receptor (GPR54) and have been thrust into the reproductive neuroendocrine spotlight as major regulators of the activity of gonadotropin-releasing hormone (GnRH) neurons.

In particular, kisspeptin expressed in GnRH neurons in the arcuate nucleus (ARC) of the mediobasal hypothalamus may be a pivotal regulator of puberty in primates and laboratory animals.

Central kisspeptin administration leads to a marked increase of luteinizing hormone (LH) in rodents, primates, and sheep, probably by stimulating GnRH secretion from GnRH neurons into portal blood.

Also, peripheral administration of kisspeptin-10 (the minimal sequence necessary for GPR54 activation) increases blood LH concentration in rats and monkeys, probably by both increasing GnRH secretion into portal blood and stimulating pituitary gonadotrophs to secret LH.

Kisspeptin may have other autocrine or paracrine, but undefined, roles in the pituitary, because rat pituitary expresses both kisspeptin and GPR54.

Technical Data for Kisspeptin 10

Purity ≥95% (HPLC)
CAS Number: 374675-21-5
PubChem ID: 25240297
M. Wt: 1302.45
Formula: C63H83N17O14
Sequence: YNWNSFGLRF
(Modification: Phe-10 = C-terminal amide)
Storage: Store at -20°C

How does Kisspeptin-10 Work?

Kisspeptin works with the nerve endings of the GnRH neurons to regulate the release of GnRH secretion. It influences the gonadotropin-releasing hormone (GnRH). These hormones play an essential role in managing testosterone and a form of estrogen.

Kisspeptin VS hcg

Kisspeptin peptides are critical in human reproductive physiology and are potential therapies for infertility. Kisspeptin-10 stimulates gonadotropin release in both male and females. While Kisspeptins are currently being studied in regards to the role of infertility, Kisspeptin-10 has been shown in many studies over the past 20 years to be an overtly effective alternative to HCG, or Human Chorionic Gonadatropin in both preventing testicular atrophy and maintaining or increasing testosterone and sperm production in males.

Kisspeptin-10, Hypogonadism and TRT

Kisspeptin-10’s benefit of increased LH concentrations in the blood can mitigate one of the common side effects of poorly-performed TRT . “Testicular atrophy” is a condition in which the testicles shrink due to the unbalanced endocrine system.

This phenomenon is caused by a reduction in the pulse frequency of LH, which is itself caused by the inhibited production of GnRH that often occurs in therapy. In the absence of GnRH, LH production by the pituitary gland ceases, LH levels drop. In turn, testosterone levels drop (signaling hypogonadism), and any achievements made thus far in therapy are reversed.

The good news is that disruptions to the hormonal feedback loop caused by TRT are largely avoidable with a number of preventative measures. This is including but not limited the administration of kisspeptin-10 alongside TRT (potentially).

Kisspeptin-10 Dose

Before determining a dosing schedule with Kisspeptin-10, you should perform blood work to measure your current FSH and LH levels. A properly titrated dosage protocol can then be developed.

Interpreting the results of a standard FSH and LH blood test is straightforward. The results will provide a figure that shows “X number of milli-international units per milliliter (mIU/mL)” – for example, “2.7 mIU/mL.”

Next, determine if your levels of LH and FSH are sufficient or if you require supplementation. Compare the number in your results to the “reference ranges” below that show normal levels of the hormones in healthy people:

Normal reference range for LH: 1.7−8.6 (mIU/mL)
Normal reference range for FSH: 1.5 to 12.4 mIU/mL

Kisspeptin Reviews

Here we have looked at some of the varying studies performed so far with Kisspeptin. It appears to have many positive results in reproduction and more. To summarize Kisspeptin influences testosterone levels and sex-related behaviors, and libido, and further research has found it can treat signs of aging. As with all research peptides, there is still more work to be done before it is allowed for use in mainstream medicine.

Atention: Kisspeptin-10 For Research Use Only

Reference:

Suttie JM, Kostyo JL, Ebling FJ, Wood RI, Bucholtz DC, Skottner A, Adel TE, Towns RJ & Foster DL 1991 Metabolic interfaces between growth and reproduction. IV. Chronic pulsatile administration of growth hormone and the timing of puberty in the female sheep. Endocrinology 129 2024– 2032.

Gottsch ML, Clifton DK & Steiner RA 2006 Kisspeptin-GPR54 signaling in the neuroendocrine reproductive axis. Molecular and Cellular Endocrinology 254–5 91– 96.

Plant TM 2006 The role of KiSS-1 in the regulation of puberty in higher primates. European Journal of Endocrinology 155 S11– S16.

Gutiérrez-Pascual E, Martínez-Fuentes AJ, Pinilla L, Tena-Sempere M, Malagón MM & Castaño JP 2007 Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinizing hormone and growth hormone secretion. Journal of Neuroendocrinology 19 521– 530.

Kotani et al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. 276 34631 PMID: 11457843

de Roux N, Genin E, Carel J-C, Matsuda F, Chaussain J-L, Milgrom E. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci U S A (2003) 100(19):10972–6. doi:10.1073/pnas.1834399100